I have the same problem with the game freezing on Windows 10 64bit no matter which settings I use, and also I can't close the game when this happens, even when I'm in windowed mode because I cannot bring other windows up in front of the game any more when this happens. I can press CTRL+ALT+DEL and get the screen where I can lock the account, open the task manager or log out/restart and the only thing that works is to log out and log on to my account again. I can also press ALT+TAB to bring up an overview of all open windows with the possibility to close them from there, but that also does not work on the game.
I could live with the game freezing from time to time, but not being able to just close it and restart again without having to log out of my windows account really makes it hard to enjoy it.